The volume of clinical trials involving CBD has grown exponentially in recent years. Cannabidiol is a compound of the cannabis plant and it is one of 113 cannabinoids in this amazing plant species. It was first discovered in the 1940s but it was not until 1963 that the exact chemical structure of CBD was uncovered. CBD derived from the cannabis plant remains a scheduled drug in the USA, however, CBD derived from the hemp plant with less than 0.3% THC is legal (as per the 2018 Farm Bill).
Research into the active properties of CBD and its applications for the treatment of a plethora of illnesses is ongoing. While its efficacy varies from person to person it remains a viable natural alternative to prescription drugs with little to no side effects.
Here is an outline of the more prominent studies that have been conducted on CBD over the past 20 years:
CBD for Pain and Arthritis
CBD has specific applications for pain and arthritis as it is anti-inflammatory in nature. CBD acts directly on the Endocannabinoid System. The ECS is integral to maintaining the immune system and the nervous system. CBD interacts with the body’s own CB1 and CB2 receptors to moderate the body’s immune response thus reducing swelling and inflammation. CBD also breaks down anandamide thus reducing inflammation.
Cytokines are molecules that are vital to the inflammation process. Covid-19 patients often experience a cytokine storm. This is the body’s response to viral particles creating inflammation and fluid in the lungs. CBD counteracts these cytokines. Research is currently being conducted on CBD’s effectiveness in helping mitigate the damage caused by COVID-19.
CBD for treating Seizures and Epilepsy
CBD Clinical trials have proven CBD to be an effective anti-convulsant.
Multicenter data from the Dravet syndrome study found that seizures were reduced by 39 percent in children treated with CBD versus only 16 percent in the placebo group. This is one of several studies conducted. These studies have shown such positive results in treating children who suffer from epilepsy that the FDA approved a CBD based drug called Epidiolex. Another positive outcome of CBD as a potential treatment is that it is very well tolerated, and it has minimal side effects. In the studies, children treated at higher doses only reported sleepiness and loose stools as side effects.
CBD has also shown effective in treating animals for seizures. It is now a go to medicine as the side effects of pharmaceutical treatments can be extremely damaging and can lead to blindness.
CBD for Nausea
Nausea is the body’s response to a potentially dangerous substance within the body. The reaction is nausea often coupled with vomiting. Simply put, CBD interacts with the Serotonin receptors to reduce nausea. People have reported being able to eat after chemotherapy when ingesting or smoking CBD. Whilst it is not an appetite stimulant it acts to reduce the sick feeling so that patients can tolerate food.
CBD dosages for nausea can be quite small. A dose of 25-50mg has shown as being amazingly effective in reducing nausea.
CBD for Anxiety
A recent study conducted by Anxiety and Depression Association of America found that over 20% of Americans over the age of 18 suffer from anxiety. Around 5% of the worldwide population suffers from anxiety. These numbers appear to be on the rise as our everyday lives become more hectic and many people spend an alarming amount of time in front of a computer screen or mobile device.
Anxiety is defined as “an emotion characterized by feelings of tension, worried thoughts and physical changes like increased blood pressure”. Oftentimes, this problem can become debilitating leaving its sufferers exhausted, sleepless and jittery.
In 2019, a study was conducted on a control group to see if CBD would help for anxiety and sleeplessness. People signed on for three months of CBD treatment, and over that period 80% of the applicants showed positive results. In fact, after one month the applicants felt better with better-reported sleep and less anxiety.
While more CBD clinical trials need to be conducted, it is very promising and shows amazing results.
CBD for Depression
Depression is a serious illness. It creates a feeling of uselessness, low self-worth, lethargy, sadness, trouble making decisions, loss of appetite and sleeplessness. Fortunately, depression is curable. If left untreated, it can lead to suicide. It is estimated that over 50% of the world’s population suffers from anxiety or depression at some point in their life.
Whilst most doctors will recommend some form and therapy and medication more and more doctors are leaning towards CBD as a first call. The reason for this is that CBD has little to no side effects, whereas pharmaceuticals can lead to very nasty side effects and it can take many months to establish the right kind of medication and necessary dosage.
The USA and the Federal Government has made it very difficult for studies to be conducted on the efficacy of CBD. CBD has been found to be highly effective in treating depression in other countries. A study in Germany found that CBD increases the level of serotonin in the body. The study showed that CBD also increased the levels of 5-HT1A and 5-HTP. Serotonin and dopamine are essential for wellbeing. A decrease in these chemicals can lead to depression and anxiety.
A 2017 study in New Zealand using 397 participants showed significant improvement in conditions, particularly those suffering from depression, anxiety, and pain. The scores increased by 13.6 points on the EQ-VAS scale after the treatments were completed over 3 weeks.
CBD for IBS
While CBD cannot cure IBS it has shown as being very effective in treating the symptoms of IBS so that the sufferer has lessened signs of IBS.
IBS stands for irritable bowel syndrome and it primarily affects the large intestine. Doctors are unsure as to why it affects only some people. Often people have symptoms on and off throughout their lives. It can be brought on by stress, diet, lifestyle, and causes bloating, cramping, diarrhea, and gas.
So how does CBD help? Since CBD works on the body’s own Endocannabinoid System (ECS) by supplying the CB1 and CBD2 receptors it is thought that CBD brings the body back into homeostasis.
Many IBS sufferers swear by CBD and its powerful healing qualities but until CBD clinical trials are completed, we will not know the full extent of CBD in treating individuals.
Until then, it is definitely a good product to try. We have had many customers who have reported taking CBD for sleep or pain and they have found it is helped but unfortunately not cured their IBS.
While more research needs to be conducted on the many applications of CBD we do know that it has shown useful for many ailments. OC Wellness Solutions provides a range of health supplements and up to date information to help individuals make an educated choice regarding their wellness regime. Many of the studies that have been conducted suggest a dosage of 200-400mg per day. It is necessary to ensure that the method of consumption reflects the amount of CBD you are taking.